Nootropics are generally used to increase cognition such as memory, focus, and concentration. However, there are some great nootropics out there for anxiety and stress reduction in addition to their cognitive benefits. These anxiolytics are known to relieve anxiety. Remember to inform your doctor you are taking any supplement as these do come with side effects and supplements can conflict with existing medications. Here are the best to try for anxiety.
Is known for its best results against social anxiety and stress. Aniracetam stimulates AMPA receptors, controlling the making and management of Glutamate. A study in 2001 done on rats concluded Aniracetam has a wide range of anti-anxiety properties and would be beneficial for anxiety and social impairments. Can help people open up in social situations as a result. It is also used for energy, focus, and motivation.
Is used to treat anxiety, depression, PTSD, and insomnia. Phenibut boosts GABA in the brain and when we are low in GABA we can have anxiety, insomnia, and restlessness. Most of the research has been done in Russia as it was discovered and developed there in the 1960’s. However, we know Phenibut increases GABA and this study shows GABA induces relaxation within 60 minutes and can diminish anxiety as a result. This one is not meant for daily use. It is powerful when used for anxiety but can have long term side effects. In the U.S. it can be found without a prescription but in other countries often you do need a prescription with it.
Is a combination of GABA and B3. Generally, people either have a preference of Phenibut or Picamilon given their GABA increasing effects. Similarly to Phenibut, it was developed in Russia around 1969 and most of the research is there as well. Here it is animal research at this time. However, as noted, with Phenibut we know what GABA does and we know Picamilon increases it. It has a more stimulating effect rather than sedative one, seen in phenibut, and also fewer side effects.
It is also a natural supplement that was known as B8 but is a sugar involved in cell signaling and as a component of the membranes of cells. A study in 2001 compared Inositol with fluvoxamine for anxiety and found it decreased the number of panic attacks significantly better than the drug and lowered anxiety.
It is 1000 times stronger than Piracetam and 200 times stronger than Aniracetam. It is also quite long lasting with one dose lasting the day. It modulates AMPA and MNDA receptors which help with Glutamate uptake. It keeps Glutamate levels stable. For anxiety, it stimulates dopamine and acetylcholine nicotinic receptors and also modulates some serotonin receptors. These will all contribute to improved mood and lowered anxiety. A study in 2001 showed that Noopept produced alpha/beta brain wave increase in 40 minutes showing relaxation effect due to the alpha wave increase and a mental boost from the beta waves.